Search for dissertations about: "conformational exchange"

Showing result 11 - 15 of 30 swedish dissertations containing the words conformational exchange.

  2. 11. Conformational Entropy and Protein Flexibility in Drug Design Studied by NMR Spectroscopy

    Author : Carl Diehl; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MMP-12; Galectin-3; confomational entropy; order parameters; ITC; Protein dynamics; isothermal titration calorimetry; macrophage elastase; nuclear magnetic resonance; NMR;

    Abstract : Proteins are complex molecules, present in all of the vital functions of life. The function of a protein is regulated by interactions between protein and other molecules. Drug design in pharmaceutical science aims to regulate the function of a protein by the design of synthesized molecules that binds to a protein with high affinity. READ MORE

  4. 12. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Author : Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Abstract : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. READ MORE

  5. 13. Structural and functional studies of microsomal glutathione transferase 1

    Author : Peter J Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione transferase; membrane protein; three-dimensional structure; elecron crystallography; hydrophobic binding stoichiometry; H D exchange mass spectrometry;

    Abstract : The microsomal glutathione transferase 1 (MGST1) is present in high amounts in the endoplasmic reticulum (ER) as an integral homo-trimeric membrane protein with a molecular weight of 51.9 kDa. READ MORE

  6. 14. Conformations of Flexible Oligosaccharides : Molecular Simulations and NMR spectroscopy

    Author : Robert Pendrill; Göran Widmalm; Jens Duus; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Oligosaccharide; Conformation; NMR spectroscopy; MD simulations; organisk kemi; Organic Chemistry;

    Abstract : The conformational preferences of several oligosaccharides are investigated herein using a combination of NMR spectroscopy and molecular dynamics (MD) simulations, focusing on the torsion angles associated with the glycosidic linkages.Strategies for obtaining usable J-HMBC spectra for carbons with an adjacent 13C label are described. READ MORE

  7. 15. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

    Author : Jerk Rönnols; Göran Widmalm; Mikael Bols; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Conformation; NMR spectroscopy; Hydrogen bond; organisk kemi; Organic Chemistry;

    Abstract : The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings.The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. READ MORE