Search for dissertations about: "congenital heart block"

Showing result 6 - 10 of 16 swedish dissertations containing the words congenital heart block.

  2. 6. Fetal echo doppler for early detection of congenital heart block

    Author : Gunnar Bergman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Fetal echo Doppler methods detecting prolonged atrioventricular (AV) time intervals, a mechanical PR interval corresponding to the electrical PR interval in ECG, have been proposed for surveillance of pregnancies at risk of complete congenital heart block (CCHB). The aim of this thesis was; to validate these Doppler methods by comparing AV time intervals from left ventricular inflow (MV), inflow and aortic outflow (MV-Ao) and superior vena cava and aortic flow (SVC-Ao) with ECG in newborns (Paper I); to investigate the significance of mechanical components in AV time prolongation (Paper II); to evaluate the diagnostic precision in a target population (Paper III) and to verify childhood outcome of fetuses, exposed to maternal anti- SSA/Ro antibodies (SSA),(Paper IV). READ MORE

  4. 7. Congenital heart block : a study of diagnostics, pathogenesis, prognosis and treatment

    Author : Håkan Eliasson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Congenital heart block (CHB) is a rare condition with considerable mortality. In most patients the disease is associated with fetal exposure to maternal SSA-Ro and/or SSB-La autoantibodies (AB) and develops in fetal life. Accuracy in fetal diagnostics is important to distinguish benign from life threatening conditions. READ MORE

  5. 8. Being born with congenital heart block : risk factors, growth and development

    Author : Amanda Skog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Congenital heart block (CHB) is a rare but life-threatening disease associated with the presence of Ro and La autoantibodies in the mother of the child affected. CHB is one of the manifestations of neonatal lupus erythematosus (NLE) that may also include several other manifestations such as a skin rash and cytopenias. READ MORE

  6. 9. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Author : Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Abstract : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. READ MORE

  7. 10. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease

    Author : Aurélie Ambrosi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. READ MORE