Search for dissertations about: "copy number analysis"

Showing result 1 - 5 of 151 swedish dissertations containing the words copy number analysis.

2. 1. Copy Number Analysis of Cancer

   Author : Markus Mayrhofer; Anders Isaksson; Simon Tavaré; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chromosomes; oncology; bioinformatics; Bioinformatik; Bioinformatics; Oncology; Onkologi; Clinical Genetics; Klinisk genetik;

   Abstract : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. READ MORE

4. 2. Computational Analysis of Tumour Heterogeneity

   Author : Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. READ MORE

5. 3. Integrative genomic and survival analysis of breast tumors

   Author : Szilard Nemes; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biostatistics; cancer; survival analysis; gemonics; DNA copy number aberrations; messenger RNA;

   Abstract : With the continued accumulation of genomic data at ever increasing resolution the challenge ahead lies in reading out meaningful clinical/biological information form the data that can contribute to a better understanding of the cancerous process. The need for novel approaches, new statistical methods is therefore strong. READ MORE

6. 4. Interpreting the Script : Image Analysis and Machine Learning for Quantitative Studies of Pre-modern Manuscripts

   Author : Fredrik Wahlberg; Anders Brun; Lasse Mårtensson; Ewert Bengtsson; Apostolos Antonacopoulos; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; document analysis; machine learning; image analysis; digital humanities; document dating; writer identification; text recognition; Datavetenskap; Computer Science;

   Abstract : The humanities have for a long time been a collection of fields that have not gained from the advancements in computational power, as predicted by Moore´s law.  Fields like medicine, biology, physics, chemistry, geology and economics have all developed quantitative tools that take advantage of the exponential increase of processing power over time. READ MORE

7. 5. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

   Author : Johan Staaf; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

   Abstract : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. READ MORE