Search for dissertations about: "coreceptor"

Showing result 6 - 10 of 35 swedish dissertations containing the word coreceptor.

  2. 6. Coreceptor usage and sensitivity to neutralization of HIV-1 and HIV-2

    Author : Yu Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; HIV-2; pathogenesis; neutralization; coreceptor usage; envelop sequence; glycosylation; U87.CD4 cells; GHOST 3 cells; CCR5; CXCR4;

    Abstract : The aim of this project was to study neutralization and coreceptor use in HIV-1 and HIV-2. The first step was to develop a simple and standardized assay for detection and quantification of HIV- 1 neutralizing activity in human sera. READ MORE

  4. 7. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Author : Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Abstract : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. READ MORE

  5. 8. Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment

    Author : Lotta Pramanik Sollerkvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immunodeficiency virus type 1 (HIV-1) group M is responsible for the HIV pandemic and has great genetic variability. The main subtypes and circulating recombinant forms belonging to this group differ in their worldwide distribution, their disease progression patterns, as well as in their coreceptor use phenotype distributions. READ MORE

  6. 9. Targeting HIV-1 entry and reverse transcription by vaccination

    Author : Bartek Zuber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; DNA vaccination; coreceptor; CCR5; RT; drug resistance; CpG; pseudovirus;

    Abstract : Human immunodeficiency virus type I (HIV-1) is a complex retrovirus, which uses the CD4 receptor and chemokine receptors to infect its target cells. The chemokine receptor CCR5 is essential for primary HIV-1 infection. The hallmark of retroviruses is the enzyme reverse transcriptase (RT), which transcribes the virus genome from RNA to DNA. READ MORE

  7. 10. HIV-1 infection during pregnancy and in children : significance of HIV-1 variability and the placental barrier

    Author : Charlotte Casper; Karolinska Institutet; Karolinska Institutet; []
    Keywords : biological phenotype; genetic subtype; chemokine receptor; coreceptor; mother- to-child transmission; placenta; disease progression; child; pregnancy;

    Abstract : With the global increase in human immunodeficiency virus 1 (HIV-1) infection in women of childbearing age, there has also been an alarming increase in the number of mother-to-child transmissions of HIV-1. Although antiretroviral therapy and Cesarian section have been demonstrated to significantly decrease the vertical transmission rate of, these interventions are not widely available in the developing world. READ MORE