Search for dissertations about: "corepressor"

Showing result 1 - 5 of 18 swedish dissertations containing the word corepressor.

  2. 1. Characterisation of the leukaemia-associated ETO homologues

    Author : Sofia Rondin Lindberg; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; SIN3B; corepressor; MTGR1; MTG16; ETO; AML1-ETO; AML; haematopoiesis; leukaemia; Hematologi; extracellulära vätskor;

    Abstract : Acute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in patients with AML. READ MORE

  4. 2. Nuclear receptor corepressor N-CoR : role in transcriptional repression

    Author : Kristina Loinder; Mats Söderström; Eckardt Treuter; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The human body consists of a multitude of cells of varying appearance and function. With a few exceptions they are genetically identical, and the key to their divergence lies in their different specific patterns of gene expression. READ MORE

  5. 3. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP

    Author : Cecilia Johansson; Catharina Svensson; Laszlo Szekely; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Adenovirus; E1A; CtBP; transcription regulation; TetON; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. READ MORE

  6. 4. Transcriptional control of liver metabolism and disease by nuclear receptor-corepressor networks

    Author : Ning Liang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Liver lipid metabolism is coordinated via transcriptional networks composed of transcription factors and coregulators. Disturbance of such networks leads to metabolic dysregulation and is linked to the progression of obesity-related metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. READ MORE

  7. 5. Modulation of nuclear receptor function by interacting proteins

    Author : Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. READ MORE