Search for dissertations about: "covalent bond"

Showing result 1 - 5 of 65 swedish dissertations containing the words covalent bond.

  2. 1. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Author : Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE

  4. 2. Insights into dynamic covalent chemistry for bioconjugation applications

    Author : Shujiang Wang; Oommen Varghese; Nicola Tirelli; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dynamic covalent chemistry; reaction mechanism; hydrogel; bioconjugation; catalysis; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Abstract : Dynamic covalent chemistry (DCC) is currently exploited in several areas of biomedical applications such as in drug discovery, sensing, molecular separation, catalysis etc. Hydrazone and oxime chemistry have several advantages, such as mild reaction conditions, selectivity, efficiency, and biocompatibility and therefore, have the potential to be for bioconjugation applications. READ MORE

  5. 3. Enzyme assays for lignin–carbohydrate bond hydrolysis

    Author : Hampus Sunner; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Enzyme kinetic param- eter estimation; Glucuronoyl esterase; Enzyme assays; Lignin-carbohydrate bonds; Synergistic enzyme assay;

    Abstract : To identify, produce, and use enzymes, analytical methods known as enzyme assays are employed. Enzyme assays are based on analysing the changes brought about on a substrate by an enzyme under defined conditions. Assays are often based on simplified reactions acting as substitutes for the reaction of interest. READ MORE

  6. 4. Secondary Interactions in Symmetric Double Bond Formation Catalysed by Molecular Ruthenium Complexes

    Author : Oleksandr Kravchenko; Licheng Sun; Roger Alberto; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; homogeneous catalysis; transition metal catalysis; ruthenium catalyst; olefin metathesis; dynamic covalent chemistry; water oxidation; solar fuels; Ru-bda; secondary interactions; hydrophobic interactions; π-π stacking; homogen katalys; övergångsmetallkatalys; rutheniumkatalysator; olefinmetates; dynamisk kovalent kemi; vattenoxidation; solbränslen; Ru-bda; sekundära interaktioner; hydrofoba interaktioner; π-π stapling; Kemi; Chemistry;

    Abstract : Chemistry has a tremendous impact on everyone’s life, although society does not always realize its power and ubiquity. In recent years, improved economy and sustainability of chemical processes has become a worldwide priority. READ MORE

  7. 5. Dynamic Covalent Resolution: Applications in System Screening and Asymmetric Synthesis

    Author : Pornrapee Vongvilai; Olof Ramström; Benjamin Miller; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dynamic covalent kinetic combinatorial resolution; Self-screening; Transesterification; Amidation; Enzyme catalysis; Nitroaldol reaction; Secondary alcohols; Strecker reaction; Aminonitriles; Racemase; Enzyme catalytic promiscuity; Chemistry; Kemi; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : Combined thermodynamic/kinetic events amount to a kinetically controlled Dynamic Combinatorial Resolution (DCR) process, where the lability of themolecules/aggregates are used to generate dynamics, and the species experiencing the lowest activation energy is selected via kinetic process. Bothinter- and intramolecular processes can be performed using this concept,resulting in complete resolution and associated amplification of the selected species. READ MORE