Search for dissertations about: "cox-1"

Showing result 11 - 15 of 36 swedish dissertations containing the word cox-1.

  2. 11. Clinical studies on the role of eicosanoids in the asthmatic airway inflammation

    Author : Kameran Daham; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate the impact of inflammatory mediators, with emphasis on eicosanoids, on the inflammatory and functional airway responses under basal and triggered conditions in subjects with asthma, in particular ASA/NSAID-intolerant and allergic phenotypes. READ MORE

  4. 12. Central Nervous System and Innate Immune Mechanisms for Inflammation- and Cancer-induced Anorexia

    Author : Johan Ruud; Anders Blomqvist; David Engblom; John-Olov Jansson; Linköpings universitet; []
    Keywords : ;

    Abstract : Anyone who has experienced influenza or a bacterial infection knows what it means to be ill. Apart from feeling feverish, experiencing aching joints and muscles, you lose the desire to eat. Anorexia, defined as loss of appetite or persistent satiety leading to reduced energy intake, is a hallmark of acute inflammatory disease. READ MORE

  5. 13. Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment

    Author : Karina Roxana Gheorghe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss of function. This condition affects 0. READ MORE

  6. 14. Studies of prostaglandin E2 formationin human monocytes

    Author : Sofia Karlsson; Jonny Wijkander; Christina Gustafson-Svärd; Karlstads universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin E2; arachidonic acid; phospholipase A2; cyclooxygenase; prostaglandin E synthase; human monocytes; Medical cell biology; Medicinsk cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. READ MORE

  7. 15. Polymyositis and dermatomyositis : inflammation, muscle structure and immunosuppressive treatment

    Author : Ingela Loell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues. The pathogenesis is not completely understood and several mechanisms are believed to be involved. READ MORE