Search for dissertations about: "cox2"
Showing result 1 - 5 of 14 swedish dissertations containing the word cox2.
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1. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
Abstract : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. READ MORE
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2. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine
Abstract : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. READ MORE
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3. Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer
Abstract : Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, an RNAdependent DNA polymerase responsible for telomere elongation. TERT is transcriptionally repressed in most normal human somatic cells with limited life-span, which contributes to telomerase silence. READ MORE
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4. Fever : Role of brain endothelial prostaglandins
Abstract : Fever and loss of appetite are two of the most fundamental manifestations of disease. These disease symptoms, which lead to deviations from normal body temperature and food intake patterns, are seen in a vast array of infectious and inflammatory conditions. READ MORE
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5. Telomerase in hematological and other malignancies : therapeutic implications
Abstract : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. READ MORE