Search for dissertations about: "crizotinib"
Showing result 1 - 5 of 9 swedish dissertations containing the word crizotinib.
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1. Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation
Abstract : Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. READ MORE
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2. Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma
Abstract : Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion partner of nucleophosmin in Anaplastic large cell lymphoma in 1994. ALK is involved in myriad of cancers including neuroblastoma which is the most common extracranial solid tumor affecting young children. READ MORE
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3. Anaplastic Lymphoma Kinase mutations and downstream signalling
Abstract : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. READ MORE
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4. Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma
Abstract : Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells of the sympathetic nervous system. READ MORE
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5. Hitting the right targets : a study of molecular mediators of sensitivity to novel potential targeted therapies in cutaneous malignant melanoma
Abstract : Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer with a 5-year overall survival (OS) rate of less than 10% among patients diagnosed with disseminated disease. During the past decade the emergence and use of novel targeted therapy and immunotherapy has significantly increased the 5-year OS rate (34%). READ MORE