Search for dissertations about: "cruzi"

Showing result 1 - 5 of 20 swedish dissertations containing the word cruzi.

  2. 1. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Author : Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. READ MORE

  4. 2. Trypanosoma cruzi genome plasticity and evolution

    Author : Carlos Talavera-López; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the parasite’s genome it has been impossible to produce a complete reference genome sequence, thus hampering the implementation of post- genomic approaches to unveil the mechanisms of generation of antigenic variation and the identification of new drug targets. READ MORE

  5. 3. Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi

    Author : Stephen O Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; Chagas´disease; karyotyping; genomic; acetyltransferase;

    Abstract : Trypanosoma cruzi (T.cruzi) is a flagellate protozoan parasite that causes Chagas' disease and is most common in Latin American countries. The disease currently infects over 13 million persons and about 100 million more are at risk. Despite basic research for many years, there is neither a vaccine nor useful drugs available to combat the disease. READ MORE

  6. 4. Detection and characterization of novel proteins in Trypanosoma cruzi

    Author : Marcela Ferella; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma cruzi is a flagellated protozoan parasite. It infects a wide range of mammals, including humans. Human T. cruzi infections are endemic to South and Central America. READ MORE

  7. 5. Gene Regulation and Epigenetic Mechanisms in the Parasite Trypanosoma cruzi

    Author : Patricia Respuela; Lena Åslund; George A.M. Cross; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; Molekylärbiologi;

    Abstract : Trypanosomes are unicellular protozoan parasites responsible for several human diseases that affect millions of people and cause thousands of casualties every year. They also represent a primitive eukaryotic model system harboring unique processes and basic regulatory mechanisms such as RNA-editing, polycistronic transcription and trans-splicing, first described in these organisms. READ MORE