Search for dissertations about: "csf dynamics"

Showing result 1 - 5 of 22 swedish dissertations containing the words csf dynamics.

  2. 1. Analysis of ICP pulsatility and CSF dynamics : the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus

    Author : Sara Qvarlander; Anders Eklund; Jan Malm; Richard Birgander; Martin U Schuhmann; Umeå universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cerebrospinal fluid; CSF dynamics; Intracranial pressure; Pulse pressure; Normal pressure hydrocephalus; Posture; Predictive tests; Mathematical modelling; Magnetic resonance imaging; Infusion tests;

    Abstract : The volume defined by the rigid cranium is shared by the brain, blood and cerebrospinal fluid (CSF). With every heartbeat the arterial blood volume briefly increases and venous blood and CSF are forced out of the cranium, leading to pulsatility in CSF flow and intracranial pressure (ICP). READ MORE

  4. 2. Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases

    Author : Juan Lantero Rodriguez; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tau; Phosphorylation; Biomarkers; Alzheimer’s disease; CSF; Blood;

    Abstract : Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau detaches from MTs, leading to neuronal dysfunction and cell death. READ MORE

  5. 3. The search for reversibility of Idiopathic normal pressure hydrocephalus : Aspects on intracranial pressure measurments and CSF volume alteration

    Author : Niklas Lenfeldt; Jan Malm; Anders Eklund; Katrine Riklund-Åhlström; John D. Pickard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Idiopathic normal pressure hydrocephalus; intracranial pressure; subcortical ischemia; neuronal integrity; cortical activation.; infusion test; cerebrospinal fluid dynamics; outflow resistance; compliance; elastance; proton spectroscopy; functional MRI; external lumbar drainage; Neurology; Neurologi;

    Abstract : BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) is still a syndrome generating more questions than answers. Today, research focuses mainly on two areas: understanding the pathophysiology – especially how the malfunctioning CSF system affects the brain parenchyma – and finding better methods to select patients benefiting from a shunt operation. READ MORE

  6. 4. Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations

    Author : Kennet Andersson; Anders Eklund; Karin Wårdell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinsk teknik; hydrocefalus; infusionstest; utflödeskonduktans; systemidentifiering; Medical technology; Medicinsk teknik;

    Abstract : Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. READ MORE

  7. 5. Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers

    Author : Antoine Leuzy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in concert, these protein opathies lead to the loss of synapses and neurons (neurodegeneration). READ MORE