Search for dissertations about: "cyanine"
Showing result 1 - 5 of 23 swedish dissertations containing the word cyanine.
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1. Groove-binding Unsymmetrical Cyanine Dyes for DNA Applications
Abstract : This work focuses on interactions between DNA and a group of newly developed unsymmetrical cyanine dyes. The aim of the work was to discover fluorescent dyes that can be used in biophysical studies of natural DNA where minimum perturbation of the DNA-helix is essential, where a slow dissociation rate of the dyes is needed and where the ionic strength is an important parameter. READ MORE
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2. Detection of Biomolecules: Syntheses and Studies of Minor Groove Binding Unsymmetrical Cyanine Dyes and Chromogenic Enzyme Substrates
Abstract : Visualisation or detection of biomolecules is usually achieved by the use of fluorescent or highly coloured chromophores. The work presented in this thesis deals with the development of new chromogenic substrates for the detection of enzyme activity, and new DNA-binding fluorescent dyes for staining of DNA. READ MORE
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3. DNA-Photosensitization by New Drugs for Photoinactivation of Viruses and Phototherapy of Tumors
Abstract : Cyanines and pyropheophorbides are two classes of photoactivable dyes which are particularly interesting for photosterilization of blood used in transfusion and for treatment of localised cancers by photodynamic therapy (PDT). After a bibliographic review about the principal mechanisms of DNA photosensitization, studies about the photosensitizing properties of these two families of compounds are presented. READ MORE
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4. Recognition and Visualization of Nucleic Acids
Abstract : The work presented in this Thesis focuses on the interaction between nucleic acids and small molecules, as well as binding or incorporation of reporter chromophores into nucleic acids. The results could help in studying and understanding processes that are fundamental to describe mechanisms behind a genetic disorder. READ MORE
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5. Development and application of advanced electron microscopy techniques for materials in biological systems
Abstract : Theoretically, electron microscopy and scanning probe microscopy offer information on a scale beyond the optical microscope. However, the quality of the micrograph and the obtained information is limited by the sample preparation. READ MORE