Search for dissertations about: "cyclin A"
Showing result 6 - 10 of 186 swedish dissertations containing the words cyclin A.
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6. The Prognostic and Treatment Predictive Value of Proliferation and TIMP-1 in Breast Cancer
Abstract : Breast cancer is the most common tumour form and the second leading cause of death in solid tumours in women in the Western world. Despite improvements in the treatment, a considerable number of patients will relapse and die from their breast cancer. READ MORE
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7. Cell cycle perspectives on breast cancer cell behaviour
Abstract : Uncontrolled proliferation and the capacity to infiltrate surrounding tissues are two important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer and basal cell carcinoma indicated that infiltrative tumour cell behaviour might be counteracted by a high proliferative activity, suggesting a coordination of these two activities at the cellular level. READ MORE
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8. Cyclin E overexpression and associated events in human breast cancer
Abstract : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. READ MORE
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9. Cyclin A1 Expression and Regulation in Hematopoietic and Leukemic Cells
Abstract : Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. READ MORE
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10. Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle
Abstract : The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. READ MORE