Search for dissertations about: "cyclin B1"
Showing result 6 - 10 of 17 swedish dissertations containing the words cyclin B1.
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6. The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms
Abstract : Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding of inhibitors, phosphorylations and subcellular localization. READ MORE
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7. Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study
Abstract : Results from clinical studies and experimental investigations have given evidence of a synergistic effect when 5- fluorouracil (5-FU) has been combined with radiation or cisplatin (CDDP). From earlier experiments performed by the research team we know, that addition of S-FU to CDDP can synergistically increase the antiproliferative effect. READ MORE
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8. No guts, no glory : EphB mediated signaling in intestinal stem and progenitor cells
Abstract : The work presented in this thesis is focused on the intestinal stem cell niche, the crypts, and the Eph tyrosine kinase receptors together with their ligands that are expressed by the crypt epithelial progenitor cells. Two fundamental cellular processes, high turnover coupled to a rapid ordered migration of the newborn cells out from the crypt, characterize the normal intestine. READ MORE
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9. The antiproliferative role of the liver X receptors in breast and colorectal cancer
Abstract : The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily of ligand activated transcription factors and have functions as regulators of lipid and glucose metabolism, as well as inflammatory response. In recent years, several reports have demonstrated an important role of LXRs in the control of cell proliferation. READ MORE
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10. Nasopharyngeal carcinoma: past, present and future directions
Abstract : Nasopharyngeal carcinoma (NPC) is a rare disease in Sweden. The purpose of this thesis was to investigate the clinicopathological manifestations of the disease and its treatment outcomes in a cohort of Swedish NPC patients to identify key features for future improvements in patient care. READ MORE