Search for dissertations about: "cyclin-dependent kinase 5"

Showing result 1 - 5 of 22 swedish dissertations containing the words cyclin-dependent kinase 5.

  2. 1. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors

    Author : Hatem H A Sallam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. READ MORE

  4. 2. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    Author : Sara Bolin; Fredrik Swartling; Martine F. Roussel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE

  5. 3. Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells

    Author : Hairong Song; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested as potential therapeutic targets and a number of pharmacologic inhibitors of CDKs and MMPs have been developed. READ MORE

  6. 4. Roles of secreted bacterial factors in modulation of host cell signalling

    Author : Eric Toh; Sun Nyunt Wai; Teresa Frisan; Staffan Bohm; Ann-Beth Jonsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteria-host interaction; motility-associated killing factor A; outer membrane vesicles; cytolysin A; phosphatidylinositol 4-phosphate 5-kinase alpha; enhancer of zeste homologue 2; epigenetic modulation; Medical Cell Biology; medicinsk cellbiologi; mikrobiologi; Microbiology;

    Abstract : Pathogenic bacteria employ several secretion systems to release or inject virulence factors that may alter host cell processes, generate a replicative niche, and aid bacterial survival in adverse environments. This thesis presents my investigations on how bacterial factors can modulate host cell signalling mechanisms. READ MORE

  7. 5. Regulation of G2 phase and long-term consequences of DNA damage

    Author : Anna Won Middleton; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated events termed ‘the cell cycle’, which ensures cell proliferation proceeds with high fidelity. READ MORE