Search for dissertations about: "cyclin-dependent kinase"
Showing result 1 - 5 of 49 swedish dissertations containing the words cyclin-dependent kinase.
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1. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
Abstract : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. READ MORE
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2. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system
Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE
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3. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases
Abstract : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. READ MORE
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4. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies
Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE
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5. Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
Abstract : Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested as potential therapeutic targets and a number of pharmacologic inhibitors of CDKs and MMPs have been developed. READ MORE