Search for dissertations about: "cyclisation"

Showing result 1 - 5 of 16 swedish dissertations containing the word cyclisation.

  2. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  4. 2. Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation

    Author : Cecilia Ericsson; Lars Engman; Ilhyong Ryu; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes free-radical reactions for the construction of tetrahydrofuran and pyrrolidine derivatives. The studies are concerned with (i) diastereoselectivity in radical cyclisation, (ii) construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones via radical carbonylation/cyclisation and (iii) synthesis of tetrahydrofuran derivatives via group-transfer cyclisation of organochalcogen compounds. READ MORE

  5. 3. Design, Synthesis and Evaluation of Catalytic Chalcogenide Antioxidants

    Author : David Shanks; Lars Engman; John C Walton; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; antioxidant; tellurium; selenium; computational design; homolytic substitution; radical cyclisation; microwave-assisted synthesis; antioxidant regeneration; Organisk kemi; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes the design, synthesis and evaluation of novel chalcogenide antioxidants.A computational model for the prediction of antioxidant properties of chalcogen-containing antioxidants has been developed. READ MORE

  6. 4. Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C

    Author : Anette Witt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alkaloids; benzodiazepines; cyclisation; Michael reactions; quinazolinones; synthesis.;

    Abstract : Benzodiazepine alkaloids exhibit a multitude of interesting pharmacological activities. This thesis deals with the development of synthetic methods towards such alkaloids, of which the main efforts can be divided into three parts. READ MORE

  7. 5. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Author : Martin H Johansson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Abstract : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. READ MORE