Search for dissertations about: "cyclooxygenase-2"

Showing result 1 - 5 of 47 swedish dissertations containing the word cyclooxygenase-2.

  1. 1. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury Effects of Selective Cyclooxygenase-2 Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tina Kunz; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. READ MORE

  2. 2. Cyclooxygenase-2 inhibitors and knee prosthesis surgery

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Andreas Meunier; Linköpings universitet.; Linköpings universitet.; Östergötlands Läns Landsting.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-steroidal anti-inflammatory agents; administration dosage; Arthroplasty; knee replacement; Surgical blood loss; Surgery; Cyclooxygenase inhibitors; Cyclooxygenase inhibitors; Fracture healing; Isoxazoles; Postoperative pain; Pyrazoles; Sulfonamides; MEDICINE Surgery; MEDICIN Kirurgi;

    Abstract : Adverse effects of cyclooxygenase (COX) inhibitors on bone healing have previously been demonstrated in diaphyseal fracture models in animals. In spite of that, they are widely used as postoperative analgesics in orthopaedic surgery. After joint replacement, a bone repair process starts at the interface between bone and cement. READ MORE

  3. 3. Luminal Hypotonicity and Duodenal Functions An Experimental Study in the Rat

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Liselotte Pihl; Uppsala universitet.; [2007]
    Keywords : Physiology; luminal alkalinization; mucosal permeability; osmolality; cyclooxygenase-2; rat; duodenum; jejunum; motility; enteric nervous system; Fysiologi;

    Abstract : After drinking water, the fluid quickly leaves the stomach thereby creating a hypotonic luminal environment in the duodenum. This in turn constitutes a potential threat to the integrity of the duodenal epithelium. It therefore seems highly likely that luminal hypotonicity activates physiological mechanisms that aim to increase luminal osmolality. READ MORE

  4. 4. Endocannabinoid metabolism the impact of inflammatory factors and pharmacological inhibitors

    University dissertation from Umeå : Umeå universitet

    Author : Jessica Karlsson; Umeå universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

    Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE

  5. 5. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

    University dissertation from Katarina Wikström, Experimental Pathology, Lund University, U-MAS, Entrance 78, 205 02 Malmö

    Author : Katarina Wikström; Lund University.; Lunds universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

    Abstract : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. READ MORE