Search for dissertations about: "cysteine protease"

Showing result 1 - 5 of 37 swedish dissertations containing the words cysteine protease.

  2. 1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB

    Author : Reine Vindebro; Ulrich von Pawel-Rammingen; Wolfgang Knecht; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Streptococcus pyogenes; Group A Streptococci; GAS; virulence factor; IdeS; SpeB; cysteine protease; protease inhibitor; IgG; immune evasion; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Abstract : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. READ MORE

  4. 2. CYSTATIN C AND NEUROENDOCRINE DIFFERENTIATION IN THE MALE REPRODUCTIVE SYSTEM AND IN PROSTATE CANCER

    Author : Thomas Jiborn; Malmö Urologisk cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; androgen deprivation therapy; cysteine protease inhibitor; neuroendocrine differentiation; cysteine protease; male reproductive tract; prostate cancer; nefrologi; Urologi; nephrology;

    Abstract : Cystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. READ MORE

  5. 3. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

    Author : Kristina Berggren; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; ; IdeS; SpeB; Papain; ; Conformational restriction; Peptidomimetics;

    Abstract : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. READ MORE

  6. 4. Streptococcal immunoglobulin degrading enzymes of the IdeS and IgdE family

    Author : Christian Spoerry; Ulrich von Pawel-Rammingen; Heiko Herwald; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Streptococcus; S. pyogenes; S. agalactiae; S. suis; S. porcinus; S. pseudoporcinus; S. equi subsp. zooepidemicus; protease; immunoglobulin; immune evasion; IdeS; IgdE; molekylärbiologi; Molecular Biology;

    Abstract : Bacteria of the genus Streptococcus are common asymptomatic colonisers of humans and animals. As opportunistic pathogens they can however, depending on their host’s immune status and other circumstances, cause mild to very severe infections. READ MORE

  7. 5. Tissue tropism among group A streptococci - importance of bacteria associated proteolytic activity

    Author : Mikael Dag Svensson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cysteine protease; plasminogen; M protein; Streptococcus pyogenes; tissue tropism; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Group A streptococcus (GAS) is one of the most common of bacterial pathogens infecting humans, frequently causing throat and skin infection. Some GAS strains have surface-expressed virulence factors called M proteins that bind human plasminogen with high affinity. READ MORE