Search for dissertations about: "cysteinyl leukotrienes"

Showing result 1 - 5 of 38 swedish dissertations containing the words cysteinyl leukotrienes.

  2. 1. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    Author : Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Abstract : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. READ MORE

  4. 2. Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells

    Author : Ladan Parhamifar; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; trafficking; Cysteinyl leukotriene receptors; inflammation; cytosolic phospholipase A2; colon cancer;

    Abstract : Inflammation is a response to injury or pathogen invasion. A large proportion of the bodie's immune system is centred in the gastrointestinal tract (GI). Prolonged inflammatory conditions of the GI have been suggested to increase the risk for developing colon cancer. READ MORE

  5. 3. Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle

    Author : Magnus Bäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2. READ MORE

  6. 4. Biosynthesis and biological role of leukotrienes in B lymphocytes

    Author : Yilmaz Mahshid; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotrienes (LT) are potent lipid mediators, synthesized from arachidonic acid (AA) upon cell activation. The essential enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), converting AA, through a two step process to LTA4. The activity of 5-LO is dependent on 5-lipoxygenase activating protein (FLAP). READ MORE

  7. 5. Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases

    Author : Hong Qiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotrienes (LTs) are a family of lipid mediators that are involved in host defense and inflammatory responses. They are synthesized from arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are divided into two classes, the classical chemoattractant leukotriene B4 (LTB4), and spasmogenic cysteinyl leukotrienes (cys-Us) including LTC4, LTD4 and LTE4. READ MORE