Search for dissertations about: "cysteinyl-leukotrienes"

Showing result 1 - 5 of 34 swedish dissertations containing the word cysteinyl-leukotrienes.

  1. 1. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Eva Wikström Jonsson; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Abstract : Functional Characterisation of Receptors for Cysteinyl Leukotrienes in Smooth Muscle by Eva Wikström Jonsson, Experimental Asthma- and Allergy Research, Institute of Environmental Medicine and Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. READ MORE

  2. 2. Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle

    University dissertation from Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Author : Magnus Bäck; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2. READ MORE

  3. 3. Human polymorphonuclear granulocytes in inflammation : studies with an emphasis on nitric oxide

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Author : Gerd Lärfars; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Polymorphonuclear granulocytes; inflammation; nitric oxide; leukotrienes; tumor necrois factor; rheumatoid arthritis; interferon-gamma; chronic granulomatous disease;

    Abstract : The function of the polymorphonuclear neutrophil granulocyte (PMN) is of vital importance in inflammation. For the defense against infections PMNs are armored with different weapons such as chemotaxis, phagocytosis and production of cytotoxic substances. READ MORE

  4. 4. Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Ladan Parhamifar; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; trafficking; Cysteinyl leukotriene receptors; inflammation; cytosolic phospholipase A2; colon cancer;

    Abstract : Inflammation is a response to injury or pathogen invasion. A large proportion of the bodie's immune system is centred in the gastrointestinal tract (GI). Prolonged inflammatory conditions of the GI have been suggested to increase the risk for developing colon cancer. READ MORE

  5. 5. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    University dissertation from Anita Sjolander

    Author : John Öhd; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). READ MORE