Search for dissertations about: "cysteinyl-leukotrienes"

Showing result 16 - 20 of 34 swedish dissertations containing the word cysteinyl-leukotrienes.

  1. 16. Studies on the regulation of leukotriene biosynthesis in antigen presenting cells

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics

    Author : Julia Esser; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Leukotrienes (LTs) are pro-inflammatory lipid mediators with important roles in host defense and inflammatory disease. Leukotriene B4 (LTB4) is a potent chemoattractant for neutrophils and contributes to bacterial killing, while the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) elicit increased vascular permeability, bronchoconstriction, eosinophil trafficking and mucus secretion. READ MORE

  2. 17. Studies on the regulation and function of lipoxygenases in Hodgkin Lymphoma

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Hongya Han; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Hodgkin lymphoma (HL) is a unique entity among the lymphomas, with a minority of malignant Hodgkin and Reed-Sternberg (H-RS) cells surrounded by a broad range of infiltrating cells. The infiltration of certain inflammatory cells has been reported to predict prognosis of the disease. READ MORE

  3. 18. Allergen-induced airway reactions in the pig in vivo : Inflammatory mediators as targets for asthma therapy

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Helena Sylvin; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : A pig model for studies of allergen-induced airway reactions has previously been developed. These pigs are actively sensitized to Ascaris suum and challenged with this antigen in the airways under anesthesia. READ MORE

  4. 19. Leukotriene C4 synthesis and export in human platelets and leukocytes : LTC4 synthase expression in normal and leukemic myeloid cells

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Author : Mikael Sjölinder; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Leukotriene (LT)C4 synthase catalyses conjugation of the unstable epoxide LTA4 with reduced glutathione and is the rate-limiting enzyme in the formation of cysteinyl leukotrienes, powerful mediators of asthma and inflammation. The presence of LTC4 synthase in platelets was demonstrated by purification and characterization of bovine platelet LTC4 synthase. READ MORE

  5. 20. Identification of arachidonic acid metabolites formed through the 15-lipoxygenase-1 pathway

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Åsa Brunnström; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The polyunsaturated fatty acid arachidonic acid is the precursor of many biologically active lipid mediators. This thesis is focused on the arachidonic acid metabolites formed through the 15-lipoxygenase-1 (15-LO-1) pathway. READ MORE