Search for dissertations about: "cysteinyl-leukotrienes"
Showing result 16 - 20 of 35 swedish dissertations containing the word cysteinyl-leukotrienes.
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16. Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodgkin lymphoma
Abstract : Classical Hodgkin lymphoma (cHL) is histologically characterized by a minority of malignant cells, the so-called Hodgkin-Reed Sternberg (H-RS) cells, surrounded by inflammatory cells such as T lymphocytes, eosinophils, macrophages and mast cells. It is generally believed that various molecules released by the H-RS cells are of major importance in the pathophysiology of cHL. READ MORE
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17. Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma
Abstract : Exercise-induced bronchoconstriction (EIB) occurs in the majority of asthmatics following vigorous exercise. EIB is caused by a loss of water from the airways creating a hyperosmolar environment in the tissue that in turn triggers the release of bronchoconstrictive mediators. READ MORE
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18. Allergen-induced airway reactions in the pig in vivo : inflammatory mediators as targets for asthma therapy
Abstract : A pig model for studies of allergen-induced airway reactions has previously been developed. These pigs are actively sensitized to Ascaris suum and challenged with this antigen in the airways under anesthesia. READ MORE
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19. Studies on the regulation of leukotriene biosynthesis in antigen presenting cells
Abstract : Leukotrienes (LTs) are pro-inflammatory lipid mediators with important roles in host de- fense and inflammatory disease. Leukotriene B4 (LTB4) is a potent chemoattractant for neutrophils and contributes to bacterial killing, while the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) elicit increased vascular permeability, bronchoconstriction, eosinophil trafficking and mucus secretion. READ MORE
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20. Leukotriene C4 synthesis and export in human platelets and leukocytes : LTC4 synthase expression in normal and leukemic myeloid cells
Abstract : Leukotriene (LT)C4 synthase catalyses conjugation of the unstable epoxide LTA4 with reduced glutathione and is the rate-limiting enzyme in the formation of cysteinyl leukotrienes, powerful mediators of asthma and inflammation. The presence of LTC4 synthase in platelets was demonstrated by purification and characterization of bovine platelet LTC4 synthase. READ MORE