Search for dissertations about: "cysteinyl-leukotrienes"
Showing result 26 - 30 of 35 swedish dissertations containing the word cysteinyl-leukotrienes.
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26. Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
Abstract : Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In research, the bronchoprovocation model represents an excellent tool to better understand asthma pathophysiology, and to assess the effects of different interventions and new investigational therapies. READ MORE
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27. Biosynthesis and biological role of leukotrienes in B lymphocytes
Abstract : Leukotrienes (LT) are potent lipid mediators, synthesized from arachidonic acid (AA) upon cell activation. The essential enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), converting AA, through a two step process to LTA4. The activity of 5-LO is dependent on 5-lipoxygenase activating protein (FLAP). READ MORE
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28. Interactions between mast cells and smooth muscle in asthma models
Abstract : Allergic asthma is the major phenotype of asthma and is characterized by specific responses to allergens as well as airway hyperresponsiveness (AHR), inflammation and remodelling. Mast cells and airway smooth muscle cells (ASM) play an important role in the allergic airway response and there are several indications that a cross-talk exists between these two cell types contributing to asthma pathogenesis. READ MORE
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29. Eicosanoids and exosomes : a link between macrophages and lung cancer
Abstract : Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these functions. READ MORE
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30. Studies of leukotriene C4 synthase isoenzymes and the cysteinyl leukotrine receptors in human endothelial- and mast cells
Abstract : Leukotriene (LT) C4, the parent compound of LTD4 and LTE4, is generated when LTA4 is conjugated with GSH by either leukotriene C4 synthase (LTC4S) or microsomal GSH S-transferase (MGST) type 2 or 3. Together these lipid mediators cause contractions particularly in airway smooth muscle and the microcirculation, leading to bronchconstriction, plasma extravasation and edema formation as well as increased mucus secretion from epithelial cells and recruitment of inflammatory cells. READ MORE
