Search for dissertations about: "cysteinyl-leukotrienes"

Showing result 6 - 10 of 35 swedish dissertations containing the word cysteinyl-leukotrienes.

  2. 6. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    Author : John Öhd; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). READ MORE

  4. 7. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Author : Astrid Bengtsson; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Abstract : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. READ MORE

  5. 8. Anti-Tumor Effects of CysLT2R in Epithelial Cancer

    Author : Cecilia Magnusson; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; migration; Colon cancer; breast cancer; EGF; interferon;

    Abstract : The pro-inflammatory cysteinyl leukotrienes (cysLTs) are implicated in several pathological disorders, such as asthma and inflammatory diseases. The well-established connection between chronic inflammation and cancer implicates inflammatory mediators in cancer progression. It is therefore of interest to examine the effects of the CysLTs in cancer. READ MORE

  6. 9. Studies on the formation of leukotriene C4 and lipoxins from leukotriene A4 in human platelets

    Author : Susanne Tornhamre; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transform the unstable epoxide leukotriene (LT)A4 to the potent inflammatory agent LTC4 and lipoxins, a group of trihydroxylated tetraene-containing eicosanoids, which recently have been suggested to have an anti-inflammatory role. A novel pathway for the formation of lipoxin (LX)A4 via platelet lipoxygenation of SS,6R-diHETE and 5S,6S-diHETE, enzymatic/non-enzymatic hydrolysis products of LTA4, was discovered in human platelets. READ MORE

  7. 10. Structural biology of integral membrane proteins - From methods to molecular mechanisms

    Author : Damian Niegowski; Pär Nordlund; Richard Neutze; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane proteins; CorA; magnesium transport; screening; Leukotriene C4 synthase; detergents; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Membrane proteins are vital components in the cell and crucial for the proliferation of all living organisms. Unfortunately our collective knowledge of structures of membrane proteins is very limited, as compared to the information available on soluble proteins. READ MORE