Search for dissertations about: "cystic fibrosis transmembrane conductance regulator"

Showing result 1 - 5 of 20 swedish dissertations containing the words cystic fibrosis transmembrane conductance regulator.

  2. 1. Mucins, Cystic Fibrosis and PDZ protein interactions

    Author : Emily Malmberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

    Abstract : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. READ MORE

  4. 2. Clinical and genetical studies in cystic fibrosis and pseudohypoaldosteronism

    Author : Charlotta Schaedel; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pseudohypoaldosteronism type 1; cystic fibrosis transmembrane conductance regulator CFTR ; Cystic fibrosis; pulmonary disorder; Pediatrics; epithelial sodium channel ENaC; Pediatri;

    Abstract : Cystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. READ MORE

  5. 3. Cystic fibrosis in adults. Diagnostic, epidemiologic and quality-of-life aspects

    Author : Marita Gilljam; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Pregnancy; Male infertility; Bronchoalveolar lavage; Quality of life; Questionnaire;

    Abstract : Background: Cystic fibrosis (CF) is a severe hereditary disease. The type of mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene will determine the degree of CFTR chloride channel malfunction. READ MORE

  6. 4. Advances in Pharmacological Treatment of Cystic Fibrosis

    Author : Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
    Keywords : Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. READ MORE

  7. 5. Towards Pharmacological Treatment of Cystic Fibrosis

    Author : Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

    Abstract : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. READ MORE