Search for dissertations about: "cytoadherence"

Showing result 1 - 5 of 12 swedish dissertations containing the word cytoadherence.

  2. 1. Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria

    Author : Andreas Heddini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; malaria; endothelial adhesion; erythrocyte rosetting; PECAM- 1 CID3 1; immunoglobulins; cerebral malaria; PfEMP- 1; var-genes;

    Abstract : Excessive sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) and uninfected erythrocytes directly blocks the microcirculation and precipitates severe symptoms from the affected organ and is thereby thought to be responsible for the severe complications which may occur during P. falciparum infection. READ MORE

  4. 2. Host cell adhesion of Plasmodium falciparum-infected erythrocytes

    Author : Carl Johan Treutiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; erythrocyte rosetting; cytoadherence; cerebral malaria; PfEMPI; serum proteins; PECAM-I CD31;

    Abstract : Excessive binding of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium (cytoadherence) and to uninfected eryrthrocytes (rosetting) are regarded as key-events in the development of a severe malaria infection. P. falciparum rosetting was confirmed to be associated with the development of cerebral malaria in The Gambia. READ MORE

  5. 3. Variant antigens at the infected red cell surface in Plasmodium falciparum malaria

    Author : Victor Fernandez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; blood stages; variant antigens; var PfEMP1; rif RIFIN; adhesive phenotypes; cytoadherence; endothelial receptor; PECAM-1 CD31; rosetting; heparan sulphate;

    Abstract : Disease severity in Plasmodium falciparum infections is, to a large extent, a consequence of the parasite's efficient escape from die human host defences. Sequestration and antigenic variation are two evasion mechanisms featured by P.falciparum. READ MORE

  6. 4. Immunological and functional properties of a non-repeat region in Plasmodium falciparum antigen Pf155/RESA

    Author : Siddique Abu Bakar; Lars Hvid; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : Plasmodium falciparum malaria is one of the most prevalent of all the great insect-borne diseases causing high morbidity and mortality in humans. As conventional anti-malarial treatment is becoming increasingly inefficient, alternative approaches to combat the parasite, like vaccine development, are of high priority. READ MORE

  7. 5. Parasite antigens and cellular interactions associated with the membrane of Plasmidium falciparum infected erythrocytes

    Author : Wipaporn Ruangjirachuporn; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The asexual erythrocytic stages of malaria parasites are the cause of the pathological manifestations of the disease, Plasmodium falciparum being the species notorious for causing serious complications. This thesis describes studies on parasite-host cell interactions at two different stages of the P. READ MORE