Search for dissertations about: "cytoadhesion"

Found 5 swedish dissertations containing the word cytoadhesion.

  2. 1. Pursuing the fever trail : pathogenesis of blood-stage P. falciparum malaria and pregnancy

    Author : Niloofar Rasti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; malaria; erythrocytes; pregnancy; Uganda; placental sequestration; cytoadhesion; PfEMP1; var2csa; antigenic variation; live-cell proteomic.;

    Abstract : The burden of the most virulent form of human malarias, Plasmodium falciparum, is concentrated among young children and pregnant women in sub-Saharan Africa. Excessive sequestration of parasite-infected red blood cells (pRBCs) in the capillary beds of different organs is the hallmark of P. READ MORE

  4. 2. Immunoglobulins in the adhesion of Plasmodium falciparum-infected erythrocytes in malaria

    Author : Carin Scholander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; rosetting; cytoodhesion; immunoglobulins; serum proteins; fibrillar structures; malarial anaemia; placental malaria; PfEMP1;

    Abstract : Characterisation of the delicate cell-to-cell interactions involved in the binding of Plasmodium falciparum- infected erythrocytes to host cells is central for the understanding of the development of severe malaria. Infected erythrocytes adhere in the deep vasculature of several organs, sequestration, leading to cerebral malaria, pulmonary oedema or renal failure. READ MORE

  5. 3. Host cell adhesion of Plasmodium falciparum-infected erythrocytes

    Author : Carl Johan Treutiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; erythrocyte rosetting; cytoadherence; cerebral malaria; PfEMPI; serum proteins; PECAM-I CD31;

    Abstract : Excessive binding of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium (cytoadherence) and to uninfected eryrthrocytes (rosetting) are regarded as key-events in the development of a severe malaria infection. P. falciparum rosetting was confirmed to be associated with the development of cerebral malaria in The Gambia. READ MORE

  6. 4. Antigenic variation and virulence in Plasmodium falciparum malaria : studies on the surface protein PfEMP1

    Author : Karin Blomqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Approximately 40% of the world’s population is at risk of contracting malaria, a disease caused by the intracellular protozoan Plasmodium. The species Plasmodium falciparum is responsible for the majority of severe morbidity and mortality. READ MORE

  7. 5. Sequestration, virulence, and future interventions in Plasmodium falciparum malaria

    Author : Fredrik Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; animal model; vaccine; adjuvant treatment;

    Abstract : The Plasmodium falciparum infected erythrocyte (iRBC) withdraws from the peripheral circulation to hide in the deep microvasculature during maturation. This phenomena, referred to as sequestration, is believed to cause extensive clogging of the vessels and contribute to die development of severe malaria. READ MORE