Search for dissertations about: "cytochrome P450 in brain"
Showing result 1 - 5 of 17 swedish dissertations containing the words cytochrome P450 in brain.
-
1. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity
Abstract : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. READ MORE
-
2. Cytochrome P450 in the rat brain : characterization and regulation
Abstract : Cytochrome P450s (CYPs) are key enzymes in the metabolism of cholesterol and fatty acids and their derivatives in the body. In the adrenals and gonads these enzymes are involved in steroid hormone biosynthesis, in the liver in bile acid synthesis, in the kidney in synthesis of the calcitropic hormone, calcitriol, and in the cardiovascular system in synthesis of thromboxane A2, a potent inducer of vasoconstriction and platelet aggregation. READ MORE
-
3. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
Abstract : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. READ MORE
-
4. Interactions between the environmental pollutant 2,3,7,8- tetrachlorodibenzo-p-dioxin and coxsackievirus infection : Experimental studies in mice
Abstract : This thesis focuses on the interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and infection. A model of human coxsackievirus type B3 (CB3) infection, adapted to A/J mice, was used.The effects on some immune cell populations and host resistance to CB3 infection were studied immediately after TCDD exposure and 3 months later. READ MORE
-
5. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish
Abstract : Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemicals that includes both pharmaceuticals and pesticides. Azole fungicides are designed to inhibit lanosterol 14-demethylase (cytochrome P450 (CYP) 51), while other azoles are intended to inhibit aromatase (CYP19), i.e. READ MORE