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Showing result 1 - 5 of 49 swedish dissertations matching the above criteria.
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1. Genetic studies on cardiovascular disease - identification of novel drug targets
Abstract : The aim of this thesis was to identify novel potential drug targets of cardiovascular disease with a focus on G-protein coupled receptors. We identified a common genetic variant of the ATP receptor P2Y11, where an alanine is substituted with a threonine at position 87 of the P2Y11 receptor that increases the risk of developing acute myocardial infarction. READ MORE
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2. A new perspective on avian phylogeny - a study based on mitochondrial genomes
Abstract : The Class Aves (birds) is generally divided into two main groups - the Palaeognathae and the Neognathae. Paleognathous birds are the flightless ratites and the tinamous, while Neognathae include all other extant birds (more than 9,000 species). READ MORE
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3. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer
Abstract : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. READ MORE
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4. Functional analysis of the alpha10beta1 integrin
Abstract : The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. READ MORE
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5. Evolutionary History of the Root Vole (Microtus oeconomus) as Revealed by Y Chromosome and Mitochondrial DNA sequences
Abstract : The root vole (Microtus oeconomus) is a rodent with Holarctic distribution. In fact, it is the only Microtus vole found in both Eurasia and North America. Phylogeographic analyses of the root vole from across its distribution range were performed using mitochondrial and Y chromosome DNA sequences. READ MORE