Search for dissertations about: "cytogenetik"
Showing result 21 - 25 of 49 swedish dissertations containing the word cytogenetik.
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21. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway
Abstract : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. READ MORE
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22. Classes of DNA associated with telomeres in the chironomids C. pallidivittatus and C. tentans
Abstract : Telomeres in Chironomus consist of long complex tandem DNA repeats, which in C. pallidivittatus have been shown to extend to the extreme end of chromosomes. In C. pallidivittatus the telomeric repeats are present in large blocks, 50-200kb in size, most of them belonging to four major subfamilies. READ MORE
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23. Linkage maps in studies of genetic variation - examples from Beta vulgaris
Abstract : Today, most studies of genetic variation utilise molecular markers, making it possible to detect variation at the DNA level. This has greatly facilitated studies of genetic variation in population and evolutionary genetics, systematics and transmission genetics. READ MORE
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24. Molecular Phylogenetics of Mammals
Abstract : In this thesis, the phylogenetic relationships of the Mammalia have been studied at various levels. Different sources of genetic information have been evaluated and used as phylogenetic markers. These include the well-known mitochondrial genome, cDNA from housekeeping genes and expressed sequence tags from nuclear genes. READ MORE
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25. Analysis of effector pathways in arthritis
Abstract : Rheumatoid arthritis (RA) is a multifactorial, polygenic autoimmune disease. For effective treatment and control of RA, understanding of disease pathways and identification of genes involved are essential. Animal models are efficient tools to identify such pathogenic mechanisms and genes underlying the disease process. READ MORE