Search for dissertations about: "cytosine arabinoside"

Found 2 swedish dissertations containing the words cytosine arabinoside.

2. 1. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

   Author : Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

   Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

4. 2. Small molecules that affect the p53 pathway and their potential use in the treatment of cancer

   Author : Marijke Cornelia Christine Sachweh; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The tumor suppressor p53 was identified 35 years ago and has since then been studied extensively, but despite all efforts, no drug or therapy directly involving it has been clinically approved - yet! A lot of potential new drugs are on their way that can reactivate p53 function by various mechanisms. Even a whole new approach called cyclotherapy has been established, during which p53 is activated in normal cells to protect patients from the adverse effects of chemotherapy while tumor cells are still being killed efficiently. READ MORE