Search for dissertations about: "cytosol"

Showing result 1 - 5 of 200 swedish dissertations containing the word cytosol.

  2. 1. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Author : Hampus Hedlund; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Abstract : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. READ MORE

  4. 2. Purification and characterization of thioltransferase (thiol: disulfide oxidoreductase) from rat liver cytosol : studies on its substrate specificity and possible biological role

    Author : Kent Axelsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This investigation describes an enzyme» from rat liver cytosol» catalyzing thiol-disulfide exchange reactions. The purification of the enzyme as well as many of its molecular characteristics are presented. READ MORE

  5. 3. How transient interactions in the crowded cytosol affect protein mobility and stability

    Author : Sarah Leeb; Mikael Oliveberg; Magnus Wolf-Watz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; diffusive transient interactions; macromolecular crowding; protein stability; in-cell NMR; protein evolution; Biophysics; biofysik;

    Abstract : Most biochemical reactions have evolved in crowded intracellular environments. However, the complexity of intracellular environments is often neglected in structural or functional studies of proteins. READ MORE

  6. 4. Cloning and characterization of canine sulfotransferases

    Author : Carrie Tsoi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Sulfotransferase; dog; cytosol; cloning; catalytic properties; mutagenesis;

    Abstract : Sulfation generally leads to an increase in hydrophilicity facilitating increased excretion of conjugated molecules. In addition, sulfation has an important role in the synthesis, metabolism and regulation of steroid hormones as well as in the generation of reactive electrophilic forms of mutagenic heterocyclic amines and hydroxymethyl polyaromatic hydrocarbons. READ MORE

  7. 5. The Francisella pathogenicity island : its role in type VI secretion and intracellular infection

    Author : Lena Meyer; Anders Sjöstedt; Siobhan C. Cowley; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; FPI; Type VI Secretion; Igl; DotU; VgrG; Pdp; microinjection; phagosomal escape; intracellular replication; Clinical Bacteriology; klinisk bakteriologi;

    Abstract : Intracellular bacteria have developed various mechanisms to enter and persist in host cells and, at the same time, to evade the host immune response. One such pathogen is Francisella tularensis, the etiological agent of tularemia. READ MORE