Search for dissertations about: "cytotoxic effects"

Showing result 1 - 5 of 264 swedish dissertations containing the words cytotoxic effects.

  2. 1. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides

    Author : Anders Herrmann; Ulf Göransson; Lars Bohlin; Douglas Kinghorn; Uppsala universitet; []
    Keywords : Pharmacognosy; cyclotide; cytotoxic; anti-tumour; macrocyclic; cyclic cystine knot; Alpine violet; Sweet violet; Viola; Violaceae; chemical modifications; structure-activity studies; mass spectroscopy; cDNA clones; Farmakognosi;

    Abstract : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. READ MORE

  4. 2. Distribution and Chemical Diversity of Cyclotides from Violaceae : Impact of Structure on Cytotoxic Activity and Membrane Interactions

    Author : Robert Burman; Ulf Göransson; Lars Bohlin; William Gerwick; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. READ MORE

  5. 3. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    Author : Jenny Felth; Lars Bohlin; Joachim Gullbo; Ulf Göransson; Thomas Efferth; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. READ MORE

  6. 4. Cyclotides : Tuning Parameters Toward Their Use in Drug Design

    Author : Mariamawit Yonathan Yeshak; Ulf Göransson; Lars Bohlin; Kaleab Asres; Robert Kiss; Uppsala universitet; []
    Keywords : cyclotide; Viola abyssinica; Viola odorata; Extraction; Violaceae; vaby; cytotoxic; genotoxic; cell penetrating; microautoradiography; LC-MS; comet assay; cycloviolacin O2; Farmakognosi; Pharmacognosy;

    Abstract : Cyclotides are plant proteins with a unique topology, defined as the cyclic cystine knot motif. The motif endows cyclotides with exceptional chemical and biological stability. They also exhibit a wide range of biological activities including insecticidal, cytotoxic, anti-HIV and antimicrobial effects. READ MORE

  7. 5. Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects

    Author : Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. READ MORE