Search for dissertations about: "cytotoxic nucleosides"

Found 5 swedish dissertations containing the words cytotoxic nucleosides.

  2. 1. Synthesis of biomolecules for nuclide therapy : Studies on amino acids, nucleosides and isoquinolines

    Author : Charlottta Naeslund; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : Nuclide therapy for cancer is based on the selective delivery of nuclide bearing compounds to tumour cells. Radionuclides, such as 125I, may be used, as well as stable isotopes, such as 10B, which is activated on site by an external neutron source. READ MORE

  4. 2. Functional aspects of wobble uridine modifications in yeast tRNA

    Author : Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. READ MORE

  5. 3. Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases

    Author : Nicola Solaroli; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside analogs. Dm-dNK is sequence related to the human deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK) and thymidine kinase 2 (M), as well as to the herpes simplex virus type-1 thymidine kinase (Hsv-1 TK). READ MORE

  6. 4. Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA

    Author : Mia Bjerke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. READ MORE

  7. 5. Translational studies on antimetabolic therapies in paediatric oncology

    Author : Nikolaos Tsesmetzis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cure rates for paediatric and adult cancer patients have improved within the last decades. This can partly be explained by implementation of new technologies and methodologies such as the identification of new mutations after sequencing that can be directly targeted for treatment or the introduction of immunotherapy. READ MORE