Search for dissertations about: "cytotoxicity studies of nanoparticles"

Showing result 1 - 5 of 11 swedish dissertations containing the words cytotoxicity studies of nanoparticles.

  2. 1. Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective

    Author : Klara Midander; Inger Odnevall Wallinder; Sannakaisa Virtanen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ferro-chromium alloy; metal particles; bioaccessibility; chemical speciation; dermal contact; surface oxide; in-vitro testing; chemical speciation; cu; copper; comet assay; intracellular; ultrafine; in vitro; A549; cytotoxicity; DNA damage; nanoparticles; particle characterization; artificial sweat; nickel release; nickel powder particles; particle loadings; release kinetics; surface area; copper release; powder particles; synthetic body fluids; simulation of interstitial lung conditions; skin contact; metal release; stainless steel; particles; test method; Surface and colloid chemistry; Yt- och kolloidkemi; Analytical chemistry; Analytisk kemi; Spectroscopy; Spektroskopi;

    Abstract : Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact. Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms. READ MORE

  4. 2. Toxicity of metal containing micro- and nanoparticles : studies from an inhalation perspective

    Author : Johanna Kain; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Particles in urban environments have for a long time been associated with different health problems and diseases, such as worsening of asthma and chronic obstructive pulmonary disease as well as cancer and cardiovascular diseases. In addition, metal containing particles present in occupational settings and industries, particularly particles produced during welding, have been linked to several adverse health effects. READ MORE

  5. 3. Toxicity and biocompatibility of nanoparticles, and studies on oxidative stress and DNA damage

    Author : Ylva Rodhe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxidative stress is associated with several diseases, either as a cause or a consequence. Chronic kidney disease (CKD) is one example of a disease in which elevated levels of oxidative stress are frequently reported. READ MORE

  6. 4. Lung toxicity of airborne nanoparticles - focus on development of an advanced in vitro exposure system

    Author : Siiri Latvala; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Inhalation exposure to airborne particles, such as nickel, increases the risk for several respiratory tract diseases. Even though the effects of nickel have been extensively studied, the data for some nickel particle types is currently inconclusive. READ MORE

  7. 5. Biocompatibility of synthetic nanomaterials and their applications in gene delivery

    Author : Jingwen Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nanomedicine is the use of nanoscale or nanostructured materials in medicine that due to their structure have unique medical effects. Prominent applications of nanomedicine are the use of nanomaterials for the delivery of drugs and nucleic acids (to correct gene defects). READ MORE