Search for dissertations about: "cytotoxicity"

Showing result 21 - 25 of 390 swedish dissertations containing the word cytotoxicity.

2. 21. Synthesis of Polymeric Nanocomposites for Drug Delivery and Bioimaging

   Author : Heba Asem; Joydeep Dutta; Moustapha Hassan; Fei Ye; Jöns Hilborn; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biodegradable polymers; SPION; QDs; drug delivery; cytotoxicity; MRI; in vivo fluorescence imaging; biodistribution; Fysik; Physics;

   Abstract : Nanomaterials have gained great attention for biomedical applications due to their extraordinary physico-chemical and biological properties. The current dissertation presents the design and development of multifunctional nanoparticles for molecular imaging and controlled drug delivery applications which include biodegradable polymeric nanoparticles, superparamagnetic iron oxide nanoparticles (SPION)/polymeric nanocomposite for magnetic resonance imaging (MRI) and drug delivery, manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs)/ SPION/ polymeric nanocomposites for fluorescence imaging, MRI and drug delivery. READ MORE

4. 22. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

   Author : Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
   Keywords : Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

   Abstract : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. READ MORE

5. 23. Biologically Interesting Compounds from Natural Sources

   Author : Veronica de la Parra; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytotoxicity; Natural products; terpenoids; vasorelaxant activity; allylmercaptane; diabetes mellitus type II; Organisk kemi; Organic chemistry; Cacalia decomposita; GPR40 receptor; TRP channel;

   Abstract : Natural products have traditionally played a major role in the drug discovery process. Besides constituting extremely popular drugs in the market, and an ever-increasing source of interesting and novel chemical structures, they have also aided the characterization of many a pharmacological target. READ MORE

6. 24. Studies of Eosinophil Cationic Protein (ECP) in vivo and in vitro : Impact of Genetic and Posttranslational Modifications

   Author : Jenny Eriksson; Per Venge; Agneta Trulson; Ester Boix; Uppsala universitet; []
   Keywords : Biomedicine; Eosinophil granulocyte; granular protein; ECP; gene polymorphism; cytotoxicity; SELDI-TOF MS; glycosylation; molecular and functional heterogeneity; fibrosis; Biomedicin;

   Abstract : Eosinophil granulocytes are tissue dwelling leukocytes that are implicated in host defence, particularly against helminthic parasites; they also participate in most inflammatory disorders. Although eosinophils have important roles in host defence mechanisms, their actions can also be harmful to the host as in the allergic inflammation where lung epithelium is destructed due to the release of toxic granule proteins. READ MORE

7. 25. Multifunctional Glyconanomaterials : Applications in Biorecognition and Drug Delivery

   Author : Zhou Juan; Ramström Olof; Ravin Narain; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; glyconanomaterials; cellulose nanocrystals; chitin nanocrystals; mesoporous silica nanoparticles; lectin; biorecognition; drug delivery; bacteria; cytotoxicity; perfluorophenylazide; fluorescent dye; carbohydrate ligands.;

   Abstract : This thesis consists of three parts, which revolve around the fabrication of multifunctional glyconanomaterials (cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles) and the development of their applications in biorecognition and nanomedicine.Part one presents a detailed introduction to glyconanomaterials, focusing on cellulose nanocrystals, chitin nanocrystals and mesoporous silica nanoparticles, including their general preparations, properties and applications. READ MORE