Search for dissertations about: "de novo designed proteins"

Showing result 1 - 5 of 13 swedish dissertations containing the words de novo designed proteins.

  2. 1. Using de novo design proteins to explore tyrosine radicals and cation-π interactions

    Author : Bruce W. Berry; Cecilia Tommos; Anders Hofer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; tyrosine; radicals; cation-pi interactions; de novo designed proteins; biochemistry; biophysics; Biochemistry; biokemi;

    Abstract : Redox cofactors and amino-acid free radicals play important roles in biology. Although many of the same cofactors and amino acids that form these radicals are found across a broad range of biological systems, identical cofactors can have different reduction potentials. The local environment plays a role in defining these redox potentials. READ MORE

  4. 2. Structural and Functional Studies of De Novo Designed Peptides at Surfaces

    Author : Patrik Nygren; Bo Liedberg; Thomas Ederth; Martin Malmsten; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biofouling; vesicles; nanoparticles; peptide; peptide design; circular dichroism; Physical chemistry; Fysikalisk kemi;

    Abstract : The work presented in this thesis deals with the structural and functional properties of peptides at surfaces. The interaction of peptides with surfaces is an ever so common occurrence in our every day life, from the bug squashed on the windshield of our car to the barnacle on our boat, and from the blood plasma used in the hospital to the proteins in our cells. READ MORE

  5. 3. Prediction, Design and Determination of Protein Structures

    Author : Sebastian Rämisch; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein design; Rosetta; Fold-and-Dock; leucine rich repeat proteins; coiled-coils; molecular replacement; ab initio phasing; temperature stability; fluorescent proteins;

    Abstract : The three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. READ MORE

  6. 4. Structural studies of heterogeneous amyloid species of lysozymes and de novo protein albebetin and their cytotoxicity

    Author : Vladimir Zamotin; Ludmilla Morozova-Roche; Daniel Otzen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid; cytotoxicity; atomic force microscopy; Biophysics; Biofysik;

    Abstract : A number of diseases are linked to protein folding problems which lead to the deposition of insoluble protein plaques in the brain or other organs. These diseases include prion diseases such as Creutzfeld-Jakob disease, Alzheimer's disease, Parkinson's disease and type II (non-insulin dependent) diabetes. READ MORE

  7. 5. The Design and Structure Prediction of Protein Oligomers

    Author : Robert Lizatovic; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Abstract : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. READ MORE