Search for dissertations about: "de novo methylation"

Showing result 1 - 5 of 11 swedish dissertations containing the words de novo methylation.

  2. 1. Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia

    Author : Noopur Thakur; Chandrasekhar Kanduri; Thomas Ekstrom; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Genomic imprinting; Imprinting control region; Antisense RNA; de novo methylation; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). READ MORE

  4. 2. Epigenetic Control of Mammalian Development : Studies on an imprinting control region

    Author : Liang Liu; Pärt Peterson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Genomic imprinting; DNA methylation; Igf2; H19; Insulator; CTCF; Imprinting control region; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; zoologisk utvecklingsbiologi; Animal Development;

    Abstract : A subset of autosomal genes is preferentially or exclusively expressed from one of the parental alleles. This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. These features are governed by a 2. READ MORE

  5. 3. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Author : Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE

  6. 4. DNA methylation and hypomethylating agents in high-risk myelodysplastic syndromes and acute myeloid leukemia

    Author : Michael Grövdal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epigenetic alterations are common in cancer. One example is aberrant hypermethylation of the promoters of tumor suppressor genes and hence silencing of gene expression. READ MORE

  7. 5. Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria

    Author : Xue Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities in cultured cells. HGPS is caused by de-novo mutations in LMNA, the gene encoding prelamin A. READ MORE