Search for dissertations about: "de novo"

Showing result 1 - 5 of 305 swedish dissertations containing the words de novo.

  2. 1. Orphan Genes Bioinformatics : Identification and properties of de novo created genes

    Author : Walter Basile; Arne Elofsson; Diethard Tautz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; de novo; orphans; evolutionary genetics; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Even today, many genes are without any known homolog. These "orphans" are found in all species, from Viruses to Prokaryotes and Eukaryotes. For a portion of these genes, we might simply not have enough data to find homologs yet. READ MORE

  4. 2. Insights into genomics and gene expression of oleaginous yeasts of the genus Rhodoturula

    Author : Giselle De La Caridad Martín Hernández; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The Rhodotorula glutinis cluster includes oleaginous yeast species with high biotechnological potential as cell factories for lipid, carotenoid, and oleochemical production. They can grow on various low-cost residues, such as lignocellulose and crude glycerol. READ MORE

  5. 3. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations

    Author : Yasmin Shamsudin Khan; Johan Åqvist; Hugo Gutiérrez de Terán; Xavier Barril; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular dynamics simulations; binding free energy; molecular docking; cyclooxygenase; non-steroidal anti-inflammatory drugs; free energy perturbation; potentials of mean force;

    Abstract : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. READ MORE

  6. 4. Strategies for de novo DNA sequencing

    Author : Anna Blomstergren; KTH; []
    Keywords : DNA sequencing; DNA purification; automation; solid-phase; streptavidin; biotin; modular probes; Helicobacter pylori; cag PAI;

    Abstract : The development of improved sequencing technologies hasenabled the field of genomics to evolve. Handling andsequencing of large numbers of samples require an increasedlevel of automation in order to obtain high throughput andconsistent quality. READ MORE

  7. 5. Using de novo design proteins to explore tyrosine radicals and cation-π interactions

    Author : Bruce W. Berry; Cecilia Tommos; Anders Hofer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; tyrosine; radicals; cation-pi interactions; de novo designed proteins; biochemistry; biophysics; Biochemistry; biokemi;

    Abstract : Redox cofactors and amino-acid free radicals play important roles in biology. Although many of the same cofactors and amino acids that form these radicals are found across a broad range of biological systems, identical cofactors can have different reduction potentials. The local environment plays a role in defining these redox potentials. READ MORE