Search for dissertations about: "degenerative diseases"

Showing result 1 - 5 of 41 swedish dissertations containing the words degenerative diseases.

  2. 1. Neurofilament light as a marker for neurodegenerative diseases

    Author : Niklas Norgren; Torgny Stigbrand; Roland Carlsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Neurofilament protein; ELISA; Cerebrospinal fluid; Neurodegenerative diseases; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Neurofilaments are the main cytoskeletal constituents in neuronal cells. They are belived to be important for maintaining the structural integrity and calibre of axons and dendrites thereby influencing the conduction velocity of nerve impulses. READ MORE

  4. 2. Degenerative changes of the human temporomandibular joint : A radiological, microscopical, histomorphometrical and biochemical study

    Author : Lennart Flygare; Göran Isacsson; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synovial Fluid; Temporomandibular Joint Diseases; Proteoglycans; Osteoarthritis; Observer variation; Microscopy; Bone density; Diagnostic properties; Image processing; Tomography; X-ray; Odontology; stomatology; Odontologi; Temporomandibular Joint Diseases; Synovial Fluid; Proteoglycans; Osteoarthritis; Observer variation; Microscopy; Bone density; Diagnostic properties; Image processing; Tomography; X-ray; Odontology; stomatology; Odontologi;

    Abstract : In five autopsy specimen studies human temporomandibular joints were investigated by conventional tomography, macroscopy, and microscopy for degenerative changes, in particular erosive hard-tissue changes.In the microscopical evaluation special attention was paid to the calcified cartilage. READ MORE

  5. 3. Novel Pharmacometric Methods for Design and Analysis of Disease Progression Studies

    Author : Sebastian Ueckert; Andrew C. Hooker; Mats O. Karlsson; Kayode Ogungbenro; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; optimal design; non-linear mixed effects models; degenerative diseases; Alzheimer s disease; item response theory; statistical power; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : With societies aging all around the world, the global burden of degenerative diseases is expected to increase exponentially. From the perspective drug development, degenerative diseases represent an especially challenging class. READ MORE

  6. 4. Mitochondrial dysfunction in ageing and degenerative disease

    Author : Anna Wredenberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The cytoplasm of eukaryotic cells contains a dynamic network of double-membraned organelles, called mitochondria, which perform the process of oxidative phosphorylation (OXPHOS) that provides cellular energy in the form of ATP. The respiratory chain creates an electrochemical gradient across the inner mitochondrial membrane, which drives ATP synthesis by the ATP synthase. READ MORE

  7. 5. Cell type-specific translatome analysis of mouse models of three genetic neurodegenerative diseases

    Author : Susanne Bauer; Walker Scott Jackson; Martin Hallbeck; Per Hammarström; Johan Jakobsson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The burden neurodegenerative diseases place on patients, their loved ones, and the healthcare system is significant, and despite extensive research efforts, there is currently no cure. Since degenerative changes in the brain can begin years before symptoms appear, early intervention is critical. READ MORE