Search for dissertations about: "dementia 2019"

Showing result 21 - 25 of 33 swedish dissertations containing the words dementia 2019.

  2. 21. Independent Ageing in Very Old Swedish Men

    Author : Kristin Franzon; Lena Kilander; Björn Zethelius; Tommy Cederholm; Jan Marcusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Independent ageing; survival; sarcopenia; comorbidity; body mass index; smoking; dietary pattern; dietary biomarkers; longitudinal; octogenarians; nonagenarians; Geriatrics; Geriatrik;

    Abstract : Predictors for survival have been investigated thoroughly, but less is known about how to reach high age with preserved physical and cognitive function. These functions are crucial to stay independent in daily life, which is highly valued by the oldest old.This thesis was based on data from the Uppsala Longitudinal Study in Adult Men. READ MORE

  4. 22. Biomarkers for Alzheimer's disease and the APOE polymorphism

    Author : Ronald Lautner; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

    Abstract : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. READ MORE

  5. 23. Probing Ligand Binding Mechanisms in Insulin-Regulated Aminopeptidases : Computational analysis and free energy calculations of binding modes

    Author : Sudarsana Reddy Vanga; Hugo Gutiérrez-de-Terán; Johan Åqvist; Efstratios Stratikos; Uppsala universitet; []
    Keywords : Docking; Molecular Dynamics; Binding free energy; Linear Interaction Energy; Free Energy Perturbation; Insulin-Regulated Aminopeptidase; Angiotensin IV; Oxytocin; Vasopressin; HA08; Aryl sulfonamides; HFI compounds.;

    Abstract : In recent years insulin-regulated aminopeptidase (IRAP) has emerged as a new therapeutic target for the treatment of Alzheimer’s disease and other memory-related disorders. So far, many potent and specific IRAP inhibitors had been disclosed, including peptides, peptidomimetics, and low-molecular-weight sulfonamides. READ MORE

  6. 24. Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies

    Author : Claudia Cicognola; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tau; fragments; Alzheimer s disease; tauopathy; cerebrospinal fluid;

    Abstract : Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and dephosphorylation. READ MORE

  7. 25. On secondary prevention after acute coronary syndrome : -what, when, and who

    Author : Daniel Huber; Thomas Mooe; Nikolai Stenfors; Annika Rosengren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular disease; acute coronary syndrome; secondary prevention; nurse-led; statins; randomized controlled trial.; kardiologi; Cardiology;

    Abstract : BackgroundCardiovascular disease, of which coronary heart disease constitutes the lion’s share, is the leading cause of premature morbidity and mortality worldwide. Management of the condition has evolved rapidly in recent decades, and mortality has more than halved in the western world. READ MORE