Search for dissertations about: "dentinogenesis"

Showing result 1 - 5 of 7 swedish dissertations containing the word dentinogenesis.

2. 1. Odontoblast phosphate and calcium transport in dentinogenesis

   Author : Patrik Lundquist; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : It has been suggested that odontoblasts are instrumental in translocating Ca2+ and inorganic phosphate (Pi) ions during the mineralization of dentin. The aim of this thesis was, therefore, to study the expression of components of the transcellular ion transport system, Na+/Ca2+ exchangers and Na+-Pi cotransporters, in odontoblastic and osteoblastic cells. READ MORE

4. 2. Clinical, histopathologic and genetic diagnosis in osteogenesis imperfecta and dentinogenesis imperfecta

   Author : Barbro Malmgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Agenesis; DSPP gene; histopathology; impaction; inherited disorders; teeth;

   Abstract : The aims of this thesis were to investigate (1) dental aberrations in a large sample of unrelated patients with different types and forms of OI, (2) degree of dentin dysplasia in relation to type and form of OI and clinical, radiographic, and microscopic manifestations and type of DI, and (3) genotypes and phenotypes in two families with DI type II with special reference to clinical, radiographic, and histopathologic manifestations. In study I, morphological and clinical variation in the expression of DI within one family was described. READ MORE

5. 3. Prevalence of dentinogenesis imperfecta and dental aberrations related to genetic findings in osteogenesis imperfecta

   Author : Kristofer Andersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous connective tissue disorder, mainly caused by mutations in COL1A1 and COL1A2, the genes encoding collagen type I. The cardinal symptoms include bone fragility and varying degrees of growth retardation. READ MORE

6. 4. Novel non-collagenous modulators of biomineralization in bone and dentin

   Author : Eszter Somogyi-Ganss; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Calreticulin; nucleobindin; prothrombin; biomineralization; osteogenesis; dentinogenesis;

   Abstract : The formation of mineralized tissues such as bones and teeth is governed on many levels by molecular, genetic, and cellular events to culminate in terminally differentiated cells that secrete a specialized organic matrix, which is later mineralized through the coordinated deposition of calcium phosphate crystals. The formation of this hard tissue phase is tightly regulated by components of the extracellular matrix (ECM), since deviations from this equilibrium result in prevalent, debilitating health problems such as arthritis, vascular calcification, periodontal disease and osteoporosis. READ MORE

7. 5. Studies on three matrix molecules in bone and dentin

   Author : Ulrika Petersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Osteoadherin OSAD ; Nucleobindin Nuc ; Calreticulin CRT ; biomineralization; osteogenesis; dentinogenesis;

   Abstract : The biomineralization of bone and dentin is a complex and dynamic process, involving the formation of an organic framework in which mineral crystals are deposited. The noncollagenous proteins (NCPs) of the organic phase play a central role in the extracellular matrix (ECM) organization and mineralization regulation. READ MORE