Search for dissertations about: "deoxycytidine kinase"

Showing result 1 - 5 of 17 swedish dissertations containing the words deoxycytidine kinase.

  2. 1. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Author : Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Keywords : Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Abstract : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. READ MORE

  4. 2. Retroviral and related nucleic acid processing enzymes expression and detection : Applications on clinical studies of HIV and HERVs

    Author : Raymond Awad; Amnon Hizi; Uppsala universitet; []
    Keywords : Medical sciences; Reverse transcriptase; endogenous retrovirus; deoxycytidine kinase; HIV; HERVS; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical Virology; medicinsk virologi;

    Abstract : Reverse transcriptase (RT), the expression and detection of the enzyme marking the family Retroviridae, has been studied. A new RT activity assay adapted to 96-well microtitre plates is described. It uses a non- radioactive bromodeoxyuridine triphosphate (BrdUTP) substrate in a solid phase format. The assay was highly sensitive. READ MORE

  5. 3. A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

    Author : Venera Kuci; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; side population; deoxycytidine kinase; resistance; SOX11; mantle cell lymphoma;

    Abstract : Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. READ MORE

  6. 4. Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA

    Author : Mia Bjerke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. READ MORE

  7. 5. Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments

    Author : Chaoyong Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; deoxyguanosine kinase; deoxycytidine kinase; nucleoside analogs; mitochondria; phosphorylation;

    Abstract : Nucleoside analogs have been developed as anticancer and antiviral agents. The main mechanism of action of nucleoside analogs is the incorporation of the corresponding analog triphosphate into DNA where it interferes with DNA replication. READ MORE