Search for dissertations about: "deoxyribonucleotides"

Showing result 1 - 5 of 28 swedish dissertations containing the word deoxyribonucleotides.

  2. 1. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Author : Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Abstract : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). READ MORE

  4. 2. The influence of nucleotides on ribonucleotide reductase assambly in class I ribonucleotide reductase from Escherichia coli

    Author : Pernilla Larsson Birgander; Britt-Marie Sjöberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Abstract : The components of DNA, the deoxyribonucleotides, are produced from the components of RNA, the ribonucleotides. One single substitution is needed to convert a ribonucleotide into a deoxyribonucleotide i.e. a replacement of a hydroxyl group with a hydrogen atom. READ MORE

  5. 3. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Author : Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; Biochemistry; Biokemi;

    Abstract : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. READ MORE

  6. 4. To reduce a ribonucleotide – Radical solutions in enzymology in form and function

    Author : Oskar Aurelius; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; X-ray crystallography; Small-angle X-ray scattering; nucleotide metabolism; protein biophysics; metalloproteins; anaerobic enzymology;

    Abstract : It has been more than 50 years since the enzyme system ribonucleotide reductase (RNR), catalysing the reduction of ribonucleotides to deoxyribonucleotides, was first discovered. RNR was also the first time that radical chemistry was revealed in an enzyme. READ MORE

  7. 5. Activation, reaction mechanism and allosteric regulation of the anaerobic ribonucleotide reductase from bacteriophage T4

    Author : Jessica Andersson; Lars Hederstedt; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Ribonucleotide reductase (RNR) catalyse the conversion of ribonucleotides to their corresponding deoxyribonucleotides in all organisms. The deoxyribonucleotides are the building blocks for DNA. Three different classes of RNR are found, class I, II and III. READ MORE