Search for dissertations about: "developmental gene expression regulation"

Showing result 1 - 5 of 142 swedish dissertations containing the words developmental gene expression regulation.

2. 1. Transcriptional and epigenetic control of gene expression in embryo development

   Author : Ann Boija; Mattias Mannervik; Jerry L. Workman; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; Cell specification; Drosophila embryo; Dorsal morphogen; CBP p300; Gene regulation; Chromatin; Promoter proximal Pol II pausing; utvecklingsbiologi; Developmental Biology;

   Abstract : During cell specification, temporal and spatially restricted gene expression programs are set up, forming different cell types and ultimately a multicellular organism. In this thesis, we have studied the molecular mechanisms by which sequence specific transcription factors and coactivators regulate RNA polymerase II (Pol II) transcription to establish specific gene expression programs and what epigenetic patterns that follows. READ MORE

4. 2. Gene regulation during development by chromatin and the Super Elongation Complex

   Author : Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

   Abstract : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. READ MORE

5. 3. Regulation of gene expression in fruit flies : how does it start, and will it be remembered?

   Author : Aman Zare; Per Stenberg; Yuri B. Schwartz; Åsa Rasmuson-Lestander; Guillaume Filion; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; epigenetics; transcription; gene regulation; transcription maintenance; CBP; polymerase pausing; Polycomb group proteins; transgenerational inheritance of transcriptional response; gut microbiome; molekylärbiologi; Molecular Biology;

   Abstract : One of the most distinctive features of eukaryotic chromosomes is the bundling of DNA together with functionally associated RNA and proteins in chromatin. This allows huge amounts of DNA to be packed inside the very tiny space of the nucleus, and alterations in the structure of chromatin enable access to the DNA for transcription (“reading” genes by production of RNA copies). READ MORE

6. 4. The Role of the Homeobox Gene ATHB16 in Development Regulation in Arabidopsis thaliana

   Author : Yan Wang; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Arabidopsis thaliana; Homeobox gene; Functional genomics; Plant development; ATHB16; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologisk botanik; Physiological Botany;

   Abstract : There are 42 members of the homeodomain-leucine zipper (HDZip) family of transcription factors in Arabidopsis thaliana. This thesis focuses on the functional analysis of one member of this family, ATHB16, and on the biochemical properties of HDZip proteins. READ MORE

7. 5. Sexually Dimorphic Gene Expression in the Mammalian Brain

   Author : Björn Reinius; Elena Jazin; Klas Kullander; Arthur Arnold; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi;

   Abstract : In recent times, major advances have been made towards understanding sexual dimorphism in the brain on a molecular basis. This thesis summarises my modest contributions to these endeavours. Sexual dimorphisms are manifested throughout the spectrum of biological complexity, and can be studied by numerous approaches. READ MORE