Search for dissertations about: "developmental screening"

Showing result 11 - 15 of 68 swedish dissertations containing the words developmental screening.

  2. 11. In vitro developmental neurotoxicity of acrylamide

    Author : Kristina Attoff; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The number of children with neurodevelopmental disorders is increasing worldwide which makes it a public concern. Exposure to environmental chemicals has been reported as a source of developmental neurotoxicity. READ MORE

  4. 12. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Author : Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  5. 13. Developmental Neurotoxicity Testing Using In vitro Approaches

    Author : Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE

  6. 14. Developmental immunotoxicity of early-life arsenic exposure

    Author : Sultan Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Arsenic exposure, mainly via drinking water and certain food, is a major public health concern because of its association with various types of cancers and other non-cancer adverse health effects. Worldwide, more than one hundred million people are exposed to elevated levels of arsenic on a regular basis. READ MORE

  7. 15. Cell models for evaluation of adult and developmental neurotoxicity : Focus on acrylamide

    Author : Kristina Attoff; Anna Forsby; Åsa Fex-Svenningsen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : This thesis is aimed at summarizing some of the alternative in vitro methods and models that have been used to study both adult and developmental neurotoxicity (DNT), and also to pinpoint some of the important aspects of using alternative in vitro methods. The aim of the papers included in this thesis was to challenge the hypothesis that neurotoxicity and DNT of chemicals can be studied using robust endpoints for proliferation and neural differentiation, such as neurite outgrowth, mRNA expression and protein expression, in two different cell lines. READ MORE