Search for dissertations about: "diabetes mice"

Showing result 1 - 5 of 275 swedish dissertations containing the words diabetes mice.

  1. 1. Dissecting the role of micro-RNAs in diabetes

    Author : Caroline Bolmeson; Create Health; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  2. 2. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

    Author : Alexander Balhuizen; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

    Abstract : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). READ MORE

  3. 3. The Perfect Storm? Gluten and type 1 diabetes

    Author : Emma Adlercreutz; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKG2D; Celiac disease autoimmunity; Gluten; Type 1 diabetes; Perinatal risk;

    Abstract : Aim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk markers and autoantibodies associated with type 1 diabetes and celiac disease during the first year after diagnosis of type 1 diabetes; to investigate the effect of gluten on the risk of developing type 1 diabetes; to evaluate the impact of perinatal factors on the risk of developing both type 1 diabetes and celiac disease. READ MORE

  4. 4. The role of CART in islet function

    Author : Mia Abels; Neuroendokrin cellbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Abstract : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. READ MORE

  5. 5. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

    Author : Anna Zetterqvist; Diabetiska komplikationer; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

    Abstract : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. READ MORE