Search for dissertations about: "diabetes type 1 2012"

Showing result 6 - 10 of 59 swedish dissertations containing the words diabetes type 1 2012.

  2. 6. Effects of Enterovirus Infection on Innate Immunity and Beta Cell Function in Human Islets of Langerhans

    Author : Oskar Skog; Gun Frisk; Olle Korsgren; Åke Lernmark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Enterovirus; Coxsackievirus; Innate immunity; Pancreatic islets; Islet function; Medicinsk vetenskap; Medical Science;

    Abstract : This thesis focuses on enteroviral effects on human pancreatic islets. Most knowledge of viral effects on host cells relies on studies of immortalized cell lines or animal models. The islets represent a fundamentally different and less well studied cellular host. Also, enterovirus has been implicated in the etiology of type 1 diabetes (T1D). READ MORE

  4. 7. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Author : Siri Malmgren; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Abstract : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. READ MORE

  5. 8. B cell deviations and type 1 diabetes in the NOD mouse

    Author : Mia Sundström; Kristina Lejon; Susanna Cardell; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type 1 diabetes; Autoimmunity; NOD mouse; Idd; TACI; Immune response; Immune complex; immunologi; Immunology;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease in which the insulin producing β-cells in the pancreatic islets of Langerhans are selectively attacked by the immune system. The β-cells are destroyed resulting in a reduced or eliminated insulin production, which in turn lead to a high blood glucose level. READ MORE

  6. 9. The initial care when a child is diagnosed with type 1 diabetes

    Author : Irén Tiberg; Institutionen för hälsovetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hemoglobin A1c; Health Resourses; Health Care Costs; Family; Home Care Resvices; Disease Management; Patient Satisfaction; Randomised Controlled Trial; Research Design; Type 1 Diabetes;

    Abstract : When a child is diagnosed with diabetes, the symptoms may be in its most severe form with ketoacidosis, to mild symptoms of diabetes, detected incidentally. Moderate and severe symptoms of diabetes presentation require infusion therapy and thereby necessitate hospitalisation for the first few days. READ MORE

  7. 10. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

    Author : Cecilia Nagorny; Diabetes - molekylär metabolism; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

    Abstract : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. READ MORE