Search for dissertations about: "diabetic rats"

Showing result 1 - 5 of 98 swedish dissertations containing the words diabetic rats.

  2. 1. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    Author : Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

  4. 2. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

    Author : Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

    Abstract : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. READ MORE

  5. 3. Altered embryonic environment and congenital malformations in diabetic pregnancy

    Author : Parri Wentzel; Uppsala universitet; []
    Keywords : Abnormalities *etiology prevention control; Animals; Diabetes Mellitus; Experimental *pathology; Dietary Supplements; Female; Folic Acid *therapeutic use; Glucose *toxicity; Neural Tube Defects etiology prevention control; Pregnancy; Pregnancy in Diabetics *physiopathology; RNA genetics isolation purification; Rats; Research Support; Non-U.S. Gov t; Tail abnormalities embryology;

    Abstract : .... READ MORE

  6. 4. Inflammatory mediators in diabetic retinopathy

    Author : Carin Gustavsson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; dyslipidemia; diabetic retinopathy; oxidative stress; TNF-alpha; VCAM-1;

    Abstract : Diabetic retinopathy (DR) is the most feared complication of diabetes with an overall prevalence of 21.9-36.8% and may, if untreated, lead to severe visual disability or blindness. READ MORE

  7. 5. Pathomechanism of diabetic nephropathy

    Author : Anna Körner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : diabetic nephropathy; hyperflltration; Na ; K - ATPase; Dahl rats; salt sensitive hypertension; glomerulosclerosis; polyol pathway activation; oxidative stress;

    Abstract : Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. However, there is a need for additional and even more efficient tools to prevent this complication of diabetes. READ MORE