Search for dissertations about: "diabetology"

Showing result 16 - 20 of 102 swedish dissertations containing the word diabetology.

  2. 16. Heritability of blood pressure: monogenes and polygenes

    Author : Cristiano Fava; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Biomedicinska vetenskaper; Biomedical sciences; kidney; Adducin-1; CLC-kb; Gitelman syndrome; association; heritabilty; genetics; hypertension; Blood pressure; blood pressure variability; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : High blood pressure (BP) is associated with cardiovascular morbidity and mortality. Both genetic and environmental factors are implicated in BP homeostatsis and hypertension development. READ MORE

  4. 17. Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion

    Author : Malin Fex; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; Lipid metabolism; Insulin secretion; Beta-cells;

    Abstract : We have investigated the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell dysfunction. READ MORE

  5. 18. Regulation of Islet Function by the Neuropeptide PACAP

    Author : Karin Filipsson; Diabetes - molekylär metabolism; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; postprandial; calcium; sodium; cAMP; intracellular signaling; glucagon; insulin; Pituitary adenylate cyclase-activating polypeptide; PACAP receptors; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : It is known that parasympathetic, sympathetic and sensory nerves innervate the islets and that these nerves harbor both classical neurotransmitters and neuropeptides. However, the neural influence on islet hormone release is complex and not yet fully understood A recently discovered pancreatic neuropeptide is pituitary adenylate cyclase-activating polypeptide (PACAP). READ MORE

  6. 19. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion

    Author : Erik Flodgren; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; GPCR; Glucagon; GPR40; Insulin; Free fatty acid; Endokrinologi; sekretion; diabetologi;

    Abstract : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. READ MORE

  7. 20. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Author : Charlotte Granhall; Genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Abstract : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. READ MORE